In this monograph, various autoimmune disorders of the nervous system have been discussed. After a brief introduction to the subject in the first chapter, various neural antibodies have been elaborated which help in understanding the disease in the second and then move on to their laboratory diagnosis in the third. In the subsequent five chapters, autoimmune disorders affecting the upper storey have been discussed including the dementias, demyelinating diseases, epilepsies, movement disorders and the cerebellar ataxias. A brief outline about the autoimmune myelopathies in the ninth chapter is followed by a sojourn into the lower storey and how the disorder affects the peripheral nerves, neuromuscular junction, and the muscle in the subsequent three chapters. Finally, different treatment options and the current guidelines are looked upon.