The sixth edition of Critical Care Update Book endeavors to comprehensively encompass the latest developments, perspectives, and pragmatic methodologies that have surfaced. The landscape of critical care medicine is constantly evolving with technological advancements, incessant research, and a profound dedication to enhancing patient outcomes. This book is intended to provide critical care practitioners a comprehensive guide to understanding the complexities of critical care Medicine and serve as evidence of the ongoing journey. The book is divided into sections on specific disorders, treatment modalities, and emerging critical care challenges for easy reading. Whether you are a critical care veteran or a newcomer, this book should be a valuable resource and inspire further research and innovation. It provides valuable insights into the recent pandemic, advancements in telemedicine in critical care, significance of big data, future of precision medicine, and the use of Omics technology to improve patient outcomes in complex critical care management.