This edition is completely changed when compared to previous edition. The vast knowledge since the last edition is incorporated to a large extent. Many new chapters are included in this edition such as Global Scenario, new concepts in Immunology, Leprosy in Special Scenario, Vaccines in Leprosy and Rehabilitation. The chapter ‘What’s New in Leprosy?’ should be helpful to answer questions in the postgraduate examinations and also tried to retain questions at the end of chapters to a possible extend. Finally, a chapter on panel discussion has been added incorporating various questions and answers discussed in various forums during the last several years.